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MK-5046 (Cat.No:I000157) is a small-molecule inhibitor of the neurokinin 1 receptor (NK1R). It works by blocking the binding of substance P to NK1R, which is involved in various physiological processes including pain transmission and inflammation.
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MK-5046 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC50 and an EC50 value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces
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90
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Merck KGaA
mk-5046 Mk 5046, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/product/mk+5046/pm26524625-45-0-9?v=Merck+KGaA Average 90 stars, based on 1 article reviews
mk-5046 - by Bioz Stars,
2026-08
90/100 stars
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MK-5046, the first BRS-3 agonist with properties suitable for use in larger mammals, has strong selectivity when binding to BRS-3 receptor. It was developed by Merck as a new approach to the treatment of obesity
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